Gene information
Official symbol EDNRA
Official full name endothelin receptor type A
Gene type protein-coding gene
Chromosome4q31.22-q31.23
Alias symbolET-A; ETA-R; hET-AR
Gene familyEndothelin receptors
Resources
Entrez Gene 1909
HGNC HGNC:3179
Ensembl ENSG00000151617
Vega OTTHUMG00000161354
UCSC uc003iky.4
GO terms: 215 records
GO Description Category LogP Number of genes Detail
GO:0001501 skeletal system development GO Biological Processes -17.2073293 69 More
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001569 branching involved in blood vessel morphogenesis GO Biological Processes -5.46031079 9 More
GO:0001653 peptide receptor activity GO Molecular Functions -6.43798881 12 More
GO:0001655 urogenital system development GO Biological Processes -19.5104956 58 More
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0001667 ameboidal-type cell migration GO Biological Processes -17.0771232 40 More
GO:0001701 in utero embryonic development GO Biological Processes -8.76987260 44 More
GO:0001755 neural crest cell migration GO Biological Processes -8.06132628 15 More
GO:0001763 morphogenesis of a branching structure GO Biological Processes -11.2402819 31 More
GO:0001822 kidney development GO Biological Processes -16.2664835 49 More
GO:0001837 epithelial to mesenchymal transition GO Biological Processes -7.70350405 17 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0001974 blood vessel remodeling GO Biological Processes -5.56777868 6 More
GO:0002009 morphogenesis of an epithelium GO Biological Processes -21.4354199 71 More
GO:0002027 regulation of heart rate GO Biological Processes -9.97103962 23 More
GO:0002064 epithelial cell development GO Biological Processes -8.05661081 27 More
GO:0003007 heart morphogenesis GO Biological Processes -18.8519524 49 More
GO:0003012 muscle system process GO Biological Processes -27.3938503 63 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003014 renal system process GO Biological Processes -10.4348518 24 More
GO:0003015 heart process GO Biological Processes -12.3962712 26 More
GO:0003018 vascular process in circulatory system GO Biological Processes -47.1670528 52 More
GO:0003151 outflow tract morphogenesis GO Biological Processes -7.88412825 17 More
GO:0003158 endothelium development GO Biological Processes -13.1102461 25 More
GO:0003205 cardiac chamber development GO Biological Processes -16.2154327 37 More
GO:0003206 cardiac chamber morphogenesis GO Biological Processes -17.7982686 34 More
GO:0003208 cardiac ventricle morphogenesis GO Biological Processes -12.9810396 22 More
GO:0003228 atrial cardiac muscle tissue development GO Biological Processes -5.92579036 8 More
GO:0003231 cardiac ventricle development GO Biological Processes -15.0525208 31 More
GO:0004435 phosphatidylinositol phospholipase C activity GO Molecular Functions -7.32266784 10 More
GO:0004620 phospholipase activity GO Molecular Functions -8.28406161 12 More
GO:0004629 phospholipase C activity GO Molecular Functions -6.96326292 10 More
GO:0006022 aminoglycan metabolic process GO Biological Processes -3.10129957 14 More
GO:0006468 protein phosphorylation GO Biological Processes -5.36604576 56 More
GO:0006576 cellular biogenic amine metabolic process GO Biological Processes -2.33647794 5 More
GO:0006584 catecholamine metabolic process GO Biological Processes -3.22341771 8 More
GO:0006816 calcium ion transport GO Biological Processes -5.55009887 27 More
GO:0006874 cellular calcium ion homeostasis GO Biological Processes -8.17100062 15 More
GO:0006939 smooth muscle contraction GO Biological Processes -6.47455620 13 More
GO:0006979 response to oxidative stress GO Biological Processes -17.6147653 58 More
GO:0007005 mitochondrion organization GO Biological Processes -2.05283627 29 More
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO Biological Processes -9.16710904 33 More
GO:0007190 activation of adenylate cyclase activity GO Biological Processes -5.90548425 6 More
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO Biological Processes -4.54895501 7 More
GO:0007202 activation of phospholipase C activity GO Biological Processes -4.61361828 8 More
GO:0007204 positive regulation of cytosolic calcium ion concentration GO Biological Processes -15.6883547 39 More
GO:0007249 I-kappaB kinase/NF-kappaB signaling GO Biological Processes -3.31231720 5 More
GO:0007292 female gamete generation GO Biological Processes -4.09618363 9 More
GO:0007411 axon guidance GO Biological Processes -2.45312404 19 More
GO:0007507 heart development GO Biological Processes -29.3002557 91 More
GO:0007517 muscle organ development GO Biological Processes -15.8908392 49 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008016 regulation of heart contraction GO Biological Processes -27.6827716 55 More
GO:0008081 phosphoric diester hydrolase activity GO Molecular Functions -7.01687804 10 More
GO:0008217 regulation of blood pressure GO Biological Processes -35.2019435 60 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0008528 G protein-coupled peptide receptor activity GO Molecular Functions -6.62401664 12 More
GO:0009308 amine metabolic process GO Biological Processes -2.23849437 5 More
GO:0009712 catechol-containing compound metabolic process GO Biological Processes -3.22341771 8 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009792 embryo development ending in birth or egg hatching GO Biological Processes -12.9988944 72 More
GO:0010517 regulation of phospholipase activity GO Biological Processes -7.06832255 9 More
GO:0010518 positive regulation of phospholipase activity GO Biological Processes -7.78358420 9 More
GO:0010827 regulation of glucose transmembrane transport GO Biological Processes -18.4601079 28 More
GO:0010863 positive regulation of phospholipase C activity GO Biological Processes -6.38368268 7 More
GO:0014029 neural crest formation GO Biological Processes -3.72261873 5 More
GO:0014033 neural crest cell differentiation GO Biological Processes -12.2997127 24 More
GO:0014075 response to amine GO Biological Processes -4.21089449 9 More
GO:0014706 striated muscle tissue development GO Biological Processes -21.0654252 44 More
GO:0014820 tonic smooth muscle contraction GO Biological Processes -3.72958795 3 More
GO:0014824 artery smooth muscle contraction GO Biological Processes -3.88065666 3 More
GO:0014829 vascular associated smooth muscle contraction GO Biological Processes -5.72938190 7 More
GO:0016049 cell growth GO Biological Processes -4.37315767 14 More
GO:0016055 Wnt signaling pathway GO Biological Processes -5.19226517 28 More
GO:0016298 lipase activity GO Molecular Functions -10.3255371 15 More
GO:0016788 hydrolase activity, acting on ester bonds GO Molecular Functions -4.57583420 56 More
GO:0018958 phenol-containing compound metabolic process GO Biological Processes -4.03177682 7 More
GO:0019725 cellular homeostasis GO Biological Processes -21.1508273 85 More
GO:0021675 nerve development GO Biological Processes -3.85527067 12 More
GO:0022898 regulation of transmembrane transporter activity GO Biological Processes -11.1988499 41 More
GO:0030001 metal ion transport GO Biological Processes -7.54203733 26 More
GO:0030203 glycosaminoglycan metabolic process GO Biological Processes -2.99315950 13 More
GO:0030855 epithelial cell differentiation GO Biological Processes -14.2408795 69 More
GO:0031175 neuron projection development GO Biological Processes -7.36986002 58 More
GO:0031279 regulation of cyclase activity GO Biological Processes -6.38196333 9 More
GO:0031281 positive regulation of cyclase activity GO Biological Processes -5.63918224 7 More
GO:0032409 regulation of transporter activity GO Biological Processes -16.9480646 53 More
GO:0032411 positive regulation of transporter activity GO Biological Processes -5.68668981 10 More
GO:0032412 regulation of ion transmembrane transporter activity GO Biological Processes -9.90560995 38 More
GO:0032414 positive regulation of ion transmembrane transporter activity GO Biological Processes -4.25838891 8 More
GO:0032835 glomerulus development GO Biological Processes -5.62617381 12 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0032989 cellular component morphogenesis GO Biological Processes -4.92421328 47 More
GO:0034599 cellular response to oxidative stress GO Biological Processes -11.6255265 36 More
GO:0034698 response to gonadotropin GO Biological Processes -7.74299764 11 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034764 positive regulation of transmembrane transport GO Biological Processes -18.2616571 46 More
GO:0034765 regulation of ion transmembrane transport GO Biological Processes -18.4305966 71 More
GO:0034767 positive regulation of ion transmembrane transport GO Biological Processes -11.2867591 18 More
GO:0035050 embryonic heart tube development GO Biological Processes -8.08177140 18 More
GO:0035051 cardiocyte differentiation GO Biological Processes -18.7205561 33 More
GO:0035150 regulation of tube size GO Biological Processes -44.5138102 41 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0035270 endocrine system development GO Biological Processes -10.2307745 25 More
GO:0035296 regulation of tube diameter GO Biological Processes -44.6572858 41 More
GO:0035850 epithelial cell differentiation involved in kidney development GO Biological Processes -3.18614571 7 More
GO:0035886 vascular associated smooth muscle cell differentiation GO Biological Processes -9.60847671 10 More
GO:0035904 aorta development GO Biological Processes -5.36863544 12 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0040007 growth GO Biological Processes -14.0580178 53 More
GO:0042310 vasoconstriction GO Biological Processes -9.70418585 13 More
GO:0042551 neuron maturation GO Biological Processes -3.82142288 8 More
GO:0042578 phosphoric ester hydrolase activity GO Molecular Functions -4.79997475 34 More
GO:0042692 muscle cell differentiation GO Biological Processes -15.1559811 45 More
GO:0043009 chordate embryonic development GO Biological Processes -11.8113315 68 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043270 positive regulation of ion transport GO Biological Processes -23.5832054 34 More
GO:0043434 response to peptide hormone GO Biological Processes -26.1739008 69 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0044752 response to human chorionic gonadotropin GO Biological Processes -6.12313579 5 More
GO:0045165 cell fate commitment GO Biological Processes -15.5778047 44 More
GO:0045446 endothelial cell differentiation GO Biological Processes -10.3072059 20 More
GO:0045761 regulation of adenylate cyclase activity GO Biological Processes -6.38434532 8 More
GO:0045762 positive regulation of adenylate cyclase activity GO Biological Processes -5.34310134 6 More
GO:0048483 autonomic nervous system development GO Biological Processes -4.59833472 10 More
GO:0048485 sympathetic nervous system development GO Biological Processes -2.72529058 5 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048562 embryonic organ morphogenesis GO Biological Processes -8.59880895 37 More
GO:0048568 embryonic organ development GO Biological Processes -17.1204114 64 More
GO:0048588 developmental cell growth GO Biological Processes -4.47857706 14 More
GO:0048589 developmental growth GO Biological Processes -14.0580178 53 More
GO:0048598 embryonic morphogenesis GO Biological Processes -22.1253699 83 More
GO:0048644 muscle organ morphogenesis GO Biological Processes -13.8992054 24 More
GO:0048706 embryonic skeletal system development GO Biological Processes -2.56739645 13 More
GO:0048729 tissue morphogenesis GO Biological Processes -31.7796969 96 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0048738 cardiac muscle tissue development GO Biological Processes -21.5979622 44 More
GO:0048754 branching morphogenesis of an epithelial tube GO Biological Processes -10.2965313 26 More
GO:0048762 mesenchymal cell differentiation GO Biological Processes -16.1250183 37 More
GO:0048771 tissue remodeling GO Biological Processes -15.8777137 28 More
GO:0048844 artery morphogenesis GO Biological Processes -13.4119116 22 More
GO:0048863 stem cell differentiation GO Biological Processes -16.2106470 36 More
GO:0048865 stem cell fate commitment GO Biological Processes -6.84857087 6 More
GO:0050801 ion homeostasis GO Biological Processes -12.0812968 60 More
GO:0051145 smooth muscle cell differentiation GO Biological Processes -9.72755777 14 More
GO:0051339 regulation of lyase activity GO Biological Processes -7.52607558 10 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051349 positive regulation of lyase activity GO Biological Processes -6.76353457 8 More
GO:0055001 muscle cell development GO Biological Processes -11.3600709 30 More
GO:0055008 cardiac muscle tissue morphogenesis GO Biological Processes -12.6682372 20 More
GO:0055067 monovalent inorganic cation homeostasis GO Biological Processes -2.09308401 6 More
GO:0055078 sodium ion homeostasis GO Biological Processes -3.02599739 4 More
GO:0055082 cellular chemical homeostasis GO Biological Processes -17.6289728 71 More
GO:0060037 pharyngeal system development GO Biological Processes -4.73205562 8 More
GO:0060070 canonical Wnt signaling pathway GO Biological Processes -4.33026410 13 More
GO:0060191 regulation of lipase activity GO Biological Processes -10.2745708 13 More
GO:0060193 positive regulation of lipase activity GO Biological Processes -9.32996784 11 More
GO:0060322 head development GO Biological Processes -11.995356 79 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0060384 innervation GO Biological Processes -3.21663541 6 More
GO:0060415 muscle tissue morphogenesis GO Biological Processes -13.8643925 23 More
GO:0060485 mesenchyme development GO Biological Processes -18.0238 46 More
GO:0060537 muscle tissue development GO Biological Processes -18.3336784 54 More
GO:0060560 developmental growth involved in morphogenesis GO Biological Processes -3.88675190 15 More
GO:0060562 epithelial tube morphogenesis GO Biological Processes -17.7630248 53 More
GO:0060840 artery development GO Biological Processes -12.7697342 25 More
GO:0060973 cell migration involved in heart development GO Biological Processes -7.86308931 9 More
GO:0061005 cell differentiation involved in kidney development GO Biological Processes -3.89325974 9 More
GO:0061061 muscle structure development GO Biological Processes -23.2569142 77 More
GO:0061138 morphogenesis of a branching epithelium GO Biological Processes -11.1441029 30 More
GO:0061307 cardiac neural crest cell differentiation involved in heart development GO Biological Processes -5.39331932 6 More
GO:0061308 cardiac neural crest cell development involved in heart development GO Biological Processes -5.39331932 6 More
GO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis GO Biological Processes -6.38728364 6 More
GO:0061437 renal system vasculature development GO Biological Processes -6.91942497 9 More
GO:0061440 kidney vasculature development GO Biological Processes -6.91942497 9 More
GO:0062197 cellular response to chemical stress GO Biological Processes -14.0979689 44 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0070588 calcium ion transmembrane transport GO Biological Processes -2.54626507 17 More
GO:0071371 cellular response to gonadotropin stimulus GO Biological Processes -6.11772924 8 More
GO:0071372 cellular response to follicle-stimulating hormone stimulus GO Biological Processes -5.39331932 6 More
GO:0071375 cellular response to peptide hormone stimulus GO Biological Processes -15.9961580 44 More
GO:0071417 cellular response to organonitrogen compound GO Biological Processes -26.3253267 90 More
GO:0072001 renal system development GO Biological Processes -17.7796243 52 More
GO:0072006 nephron development GO Biological Processes -8.44009723 23 More
GO:0072009 nephron epithelium development GO Biological Processes -6.83107535 18 More
GO:0072010 glomerular epithelium development GO Biological Processes -3.31496494 6 More
GO:0072012 glomerulus vasculature development GO Biological Processes -7.35783353 9 More
GO:0072073 kidney epithelium development GO Biological Processes -9.16824163 24 More
GO:0086103 G protein-coupled receptor signaling pathway involved in heart process GO Biological Processes -5.67855223 6 More
GO:0090066 regulation of anatomical structure size GO Biological Processes -32.7608623 52 More
GO:0090497 mesenchymal cell migration GO Biological Processes -8.76593708 16 More
GO:0097084 vascular associated smooth muscle cell development GO Biological Processes -7.18867136 7 More
GO:0097485 neuron projection guidance GO Biological Processes -2.79075716 20 More
GO:0097746 blood vessel diameter maintenance GO Biological Processes -44.6572858 41 More
GO:0098655 cation transmembrane transport GO Biological Processes -3.98966777 20 More
GO:0098660 inorganic ion transmembrane transport GO Biological Processes -4.47276690 21 More
GO:0098662 inorganic cation transmembrane transport GO Biological Processes -4.65654157 20 More
GO:0198738 cell-cell signaling by wnt GO Biological Processes -5.19226517 28 More
GO:1900274 regulation of phospholipase C activity GO Biological Processes -6.23203613 7 More
GO:1901615 organic hydroxy compound metabolic process GO Biological Processes -22.7091625 41 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1901653 cellular response to peptide GO Biological Processes -21.5212108 58 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1903510 mucopolysaccharide metabolic process GO Biological Processes -2.64314024 10 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1904062 regulation of cation transmembrane transport GO Biological Processes -18.6629834 61 More
GO:1904064 positive regulation of cation transmembrane transport GO Biological Processes -10.8655330 17 More
GO:1904888 cranial skeletal system development GO Biological Processes -2.01258862 8 More
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling GO Biological Processes -7.80587066 38 More
GO:1905144 response to acetylcholine GO Biological Processes -4.09043632 8 More
GO:1990138 neuron projection extension GO Biological Processes -1.34306851 3 More
GO:2001257 regulation of cation channel activity GO Biological Processes -11.2578208 33 More
GO:2001259 positive regulation of cation channel activity GO Biological Processes -4.43623555 7 More
KEGG pathways: 6 records
KEGG Description Category LogP Number of genes Detail
hsa04020 Calcium signaling pathway KEGG Pathway -10.4415222 36 More
hsa04022 cGMP-PKG signaling pathway KEGG Pathway -9.74555098 16 More
hsa04024 cAMP signaling pathway KEGG Pathway -7.78464854 30 More
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
hsa04924 Renin secretion KEGG Pathway -9.25913478 11 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
Drug-Gene interaction
view
Related drugs: 16 records
Drug name Interaction type Source PMID View
ambrisentan antagonist TdgClinicalTrialChemblInteractionsTENDTTD 19601701193898761992091320811346 view
atrasentan antagonist TdgClinicalTrialTTD 165636291645841712563310 view
atrasentan hydrochloride antagonist ChemblInteractions view
avosentan antagonist TdgClinicalTrialChemblInteractions view
bosentan antagonist TdgClinicalTrialChemblInteractionsTENDTTD 109613751170456511728166114473071175235211849873 view
bq-123 antagonist TTD view
clazosentan antagonist TdgClinicalTrialChemblInteractionsTTD 16219361 view
darusentan antagonist TdgClinicalTrialChemblInteractionsTTD 1789087017049116 view
enrasentan antagonist ChemblInteractions 16219361 view
irl-1620 TdgClinicalTrial view
macitentan antagonist TdgClinicalTrialChemblInteractionsTTD 224583472286229424261583 view
nebentan antagonist TdgClinicalTrialChemblInteractionsTTD 21232046 view
sitaxentan antagonist TdgClinicalTrial 10961375117045651172816617472992114473071175235211849873 view
sparsentan antagonist ChemblInteractionsTTD view
tezosentan antagonist ChemblInteractions 15542526 view
zibotentan antagonist TALCTdgClinicalTrialChemblInteractions view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
NM_001957.4:c.-231A>G genomics myocardial infarction[diagnosis] myocardial infarction Oguri M et al. Atherosclerosis. 2009
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